r/StarvingCancer Nov 17 '24

Discussion of genetic vs metabolic

2 Upvotes

r/StarvingCancer Oct 06 '24

2-Deoxy-D-Glucose

4 Upvotes

Has anyone heard about or tried this metabolic medication?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141706/

Title: Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1

Authors: Federico Lucantoni, Heiko Dussmann, and Jochen H. M. Prehn

Abstract Summary:

• Background:
• Breast cancer cells exhibit metabolic flexibility, utilizing both glycolysis (the breakdown of glucose without oxygen) and mitochondrial oxidative phosphorylation (OXPHOS) to meet their energy demands.
• Triple-negative breast cancer (TNBC) cells rely heavily on glycolysis, while estrogen receptor-positive (ER+) breast cancer cells depend more on OXPHOS.
• Targeting these metabolic pathways presents an opportunity for cancer therapy.
• Key Findings:
• MDIVI-1 Effects on Mitochondria:
• MDIVI-1, known as a mitochondrial fission inhibitor, was found to alter mitochondrial bioenergetics at concentrations that do not affect mitochondrial morphology.
• It inhibits mitochondrial complex I-dependent oxygen consumption, affecting the cell’s energy production.
• Compensatory Increase in Glycolysis:
• When mitochondrial function is impaired by MDIVI-1, breast cancer cells increase glycolysis to compensate for the loss of energy production from mitochondria.
• Dual Targeting Strategy:
• The study combined MDIVI-1 with 2-deoxy-D-glucose (2-DG), a glycolysis inhibitor.
• This combination reduced overall cellular bioenergetics, increased cell death, and decreased the ability of breast cancer cells to form colonies.
• Both ER+ (MCF7) and HER2+ (HDQ-P1) breast cancer cell lines were effectively targeted.
• Conclusion:
• Dual inhibition of glycolysis and mitochondrial bioenergetics presents a promising therapeutic approach for breast cancer treatment.

Implications for Breast Cancer Treatment:

1.  Metabolic Vulnerabilities:
• Breast cancer cells have high metabolic demands and are often more reliant on specific pathways than normal cells.
• Targeting both glycolysis and mitochondrial respiration can exploit these vulnerabilities.
2.  MDIVI-1 as a Therapeutic Agent:
• Originally developed as a mitochondrial fission inhibitor, MDIVI-1’s role in inhibiting mitochondrial complex I suggests a new application in cancer therapy.
• By impairing mitochondrial energy production, MDIVI-1 forces cancer cells to rely more on glycolysis.
3.  Combination Therapy Enhances Efficacy:
• Using MDIVI-1 in combination with 2-DG effectively cuts off both major energy sources for cancer cells.
• This leads to energy depletion, cell death, and reduced tumorigenic potential.
4.  Applicability to Different Breast Cancer Subtypes:
• The strategy was effective in both ER+ and HER2+ breast cancer cell lines.
• While TNBC cells primarily rely on glycolysis, ER+ and HER2+ cells use both glycolysis and OXPHOS, making them suitable targets for this dual inhibition.

Challenges and Considerations:

• Selectivity and Toxicity:
• Mitochondrial inhibitors can also affect normal cells, so ensuring selectivity is crucial.
• MDIVI-1’s impact on normal cells needs to be thoroughly evaluated.
• Clinical Translation:
• The study was conducted in vitro using cell lines.
• Further research, including animal studies and clinical trials, is necessary to determine the safety and effectiveness in humans.
• Mechanism of Action Clarification:
• Recent research suggests that MDIVI-1’s primary action may be inhibiting mitochondrial complex I rather than its originally proposed role as a Drp1 inhibitor.
• Understanding the exact mechanism is essential for optimizing therapeutic strategies.

Conclusion:

The study presents a promising approach to breast cancer treatment by simultaneously targeting glycolysis and mitochondrial respiration. MDIVI-1, in combination with 2-DG, effectively impairs cancer cell metabolism, leading to increased cell death and reduced tumorigenic potential. This dual-targeting strategy could be particularly effective against breast cancer subtypes that rely on both glycolysis and OXPHOS for energy production.


r/StarvingCancer Oct 06 '24

Jane McLelland's website

2 Upvotes

Links to her book, podcasts, and her online course all designed to stop/slow cancer's growth by taking away it's fuel (without starving the normal processes).

https://www.howtostarvecancer.com


r/StarvingCancer Sep 29 '24

Starving Cancer by cutting off it’s favorite foods (glucose and glutamine)

3 Upvotes

AMERICAN COUNCIL ON SCIENCE AND HEALTH

Oct 2019

"Reporting in the journal Cell Chemical Biology, a team of researchers led by Elena Reckzeh describe the discovery of a new, high-potency molecule (which they called Glutor) that blocked several varieties of the glucose transport protein. This is significant because previous inhibitors were low potency and/or only blocked one kind of glucose transport protein.

The first image depicts the molecular mechanism of their proposed chemotherapeutic strategy. The first part of the strategy involves treating cancer with Glutor, which will shut down glucose metabolism. Indeed, the authors showed that 44 different cancer cell lines were potently inhibited by Glutor in vitro. Non-cancerous cell lines were not inhibited.

The second leg of their strategy involves blocking an enzyme responsible for metabolizing glutamine. When the treatments are combined, they act together to suppress cancer cell growth. (See second image. The blue region depicts the synergy of the two drugs acting in concert.)"

https://www.acsh.org/news/2019/10/02/starving-cancer-cutting-its-favorite-foods-glucose-and-glutamine-14314


r/StarvingCancer Sep 17 '24

Starving Cancer TED Talk by Sarah Lunt

2 Upvotes

r/StarvingCancer Sep 06 '24

Jane McLelland's Private Facebook Group (94k members at the time of this writing)

1 Upvotes

Link to Jane's Facebook Group which offers more information about Jane's Protocol: https://www.facebook.com/groups/off.label.drugsforcancer/?ref=share


r/StarvingCancer Aug 24 '24

Statement about benefit of taking doxycycline

1 Upvotes

r/StarvingCancer Aug 22 '24

Share your story

2 Upvotes

Hi, please share your story in the comments below. You might want to mention when you were diagnosed, what type of cancer you have, when and how you became familiar with the Starving Cancer protocol, and how your treatments are going for you.


r/StarvingCancer Aug 22 '24

Jane McLelland on Spotify

1 Upvotes

r/StarvingCancer Aug 15 '24

Improving Early Detection by Utilizing AI

1 Upvotes

Publisher: Journal of Clinical Oncology

Date: May 29, 2024

Lead: Bakshi

Link: https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.1560


r/StarvingCancer Jul 27 '24

References to take to Dr

1 Upvotes

My general practitioner is working with me on the nutrition/exercise/supplement side of things. I told her about this book and how so many people had success. I want to be able to take some references to her or an outline. What do you suggest as material to show your Dr?


r/StarvingCancer Jul 22 '24

How to find a doctor to help you follow Jane McLelland's Starving Cancer Protocol

1 Upvotes

As stated on the Care Oncology website:

Since 2013 Care Oncology has been treating cancer patients, with multiple cancer types, using our patented COC Protocol™. The COC Protocol is a metabolic therapy that uses a combination of conventional pharmaceuticals which may work together to restrict the overall ability of cancer cells to take up and use (i.e., ‘metabolize’) energy.

https://careoncology.com


r/StarvingCancer Jul 18 '24

Starving Cancer Zoom Panel Discussion with Jane McLelland

1 Upvotes

Video: zoom panel with Jane McLelland

"The Role of Metabolic Therapies in Cancer"

8/1/22

Length: 1h 20min

https://www.youtube.com/watch?v=s11I5M0fegc


r/StarvingCancer Jul 18 '24

Interview with Jane McLelland

1 Upvotes

Interview with Jane McLelland - by Chris Wark

Released: April 3, 2019

Length: 1hour, 6 minutes

https://www.youtube.com/watch?v=qReudtklq9Y


r/StarvingCancer Jul 18 '24

Jane’s X/Twitter account

1 Upvotes

More information: link to Jane McLelland’s X (Twitter) account https://twitter.com/jane_mclelland?lang=en


r/StarvingCancer Jul 18 '24

Opening on the mod team

1 Upvotes

If interested, please apply by modmail. No mod experience required. I have no plans to leave. Not a lot of work required. I would like a back up person rather than do this alone.


r/StarvingCancer Jun 19 '24

Interview with Jane McLelland

1 Upvotes

March 12, 2022

IRise Above Foundation

https://www.youtube.com/watch?v=kbkma3UKpZI


r/StarvingCancer Jun 14 '24

A Three-Prong Approach to Slowing Cancer

5 Upvotes

Although Jane McLelland’s strategies are complex, the core of her approach is this: cancer has 3 main fuel sources:

  1. Fat

  2. Sugar

  3. Protein

These are fuels your body needs to survive.

There are ways you can limit the amount of fuel cancer cells can access (while still getting the healthy/normal cells the nutrients/fuel they need):

  1. Reduce cancer's access to fat fuel with Lovastatin.

  2. Reduce cancer's access to sugar fuel with Metformin.

  3. Reduce cancer's access to protein fuel with Dipyridamole.


r/StarvingCancer Jun 13 '24

The Metabolic Approach to Living with Cancer

3 Upvotes

From the Netherlands.

Includes discussion of Jane McLelland’s Metro Map.

https://beterkliniek.nl/en/metabole-ondersteuning-bij-kanker/


r/StarvingCancer Jun 13 '24

But what are the critics saying about Jane McLelland?

1 Upvotes

She was given a 3 month prognosis.

She is alive 30 years later.

But in the interest of full disclosure, what do her critics say?

One commenter wrote:

Just be careful about recomending Jane McCllelland. She’s gone full on anti-vax, promotes ivermectin as a tnbc cure, claims alternative medicine cured her cancer while not mentioning all the traditional therapies she had (chemo, tamoxifen), advances ideas about cancer that just aren’t true.

”Unfortunately, however, Ms. McClelland, Dr. Lawrie’s claim that she is a “TOP scientist” notwithstanding, is a fake expert, who claims that her self-discovered knowledge trumps that of experts who have formal training and have devoted their lives to studying cancer and/or treating cancer patients. For one thing, she has no training in oncology or scientific research, being a Chartered Physiotherapist who worked in the UK’s NHS and private practice for twelve years, specialising in Neurology and then Orthopaedic.” https://sciencebasedmedicine.org/tess-lawrie-ivermectin-isnt-just-for-covid-19-but-cures-cancer-too/


r/StarvingCancer Jun 13 '24

Jane McLelland’s Timeline

1 Upvotes
  • 1994: cervical cancer, with spread to lymph nodes. Treatment: chemo, radiotherapy, and hysterectomy

  • 1999: spread to lungs. Chemo and surgery.

  • 2004: myelodysplasia (can lead on to leukemia), changes in blood: P 53 deleted/absent, could hardly walk from the bathroom to my bed, short of breath.

  • started reading research (from the 80s, Elizabeth Rhodes in The Lancet and The Townsend Letter).

  • Started a drug combination not often used for cancer (these drugs allow your body to access the nutrients it needs, while blocking the cancer’s access to them). The goal is to cut off all fuel sources at the same time in order to effectively weaken cancer.

reduce cancer’s fat fuel with a common statin drug (Lovastatin)

reduce cancer’s glucose fuel with a common diabetes drug (Metformin) and an anti-worming drug Mebendazole.

reduce cancer’s protein fuel with an anti-platelet drug (Dipyridamole (DIP))

kill cancer cells by adding a non steroidal anti inflammatory drug (NSAID, etodolac)

kill cancer cells with high dose intravenous Vitamin C

add an antibiotic (Doxycycline) which slows the creation of new cancer cells

  • 2018: published her approach in a book

  • alive 30 years after first cancer diagnosis. Blood tests revealed that her TM2PK tumor markers (a marker of abnormal glycolysis) had dropped from 397 to 21.5—just slightly above a “normal” reading of 15.


r/StarvingCancer May 02 '24

News article

1 Upvotes

Oct 27, 2018

Daily Mail

Medications mentioned - some of the most commonly taken in the world:

  • type 2 diabetes treatment metformin

  • cholesterol-busting statins

  • aspirin

  • dipyridamole, a drug often given to stroke patients for clot-prevention.

  • Jane’s cancer treatment included conventional treatments (radiation in 1994 plus chemotherapy in 1994 and 1999), dendritic cell vaccine in 2000, and supplements, including intravenous Vitamin C, and radically changed her diet.

https://www.dailymail.co.uk/health/article-6323993/amp/How-secret-surviving-cancer-inside-medicine-cabinet.html


r/StarvingCancer Apr 30 '24

Study: glucose deprivation kills cancer cells due to ROS (not ATP)

2 Upvotes

Lead: Kang (National Cancer Center, Korea)

Published: International Journal Molecular Science, July 26, 2023

Type of study: cellular

Conclusion: "In this study, we found that glucose deprivation triggers cell death following an increase in ROS levels that was inversely correlated with ATP production. The increase of ROS induced cell death was concomitant with a decrease in ATP levels. Treatment with the reducing agent NAC reversed cancer cell death after restoration of ATP levels in cells under glucose deprivation. These findings suggest that ATP depletion resulting from glucose deprivation is not the cause of cancer cell death, but rather the result of cancer cell death caused by failure of ROS regulation. Indeed, glucose deprivation-induced cell death is independent from ATP depletion-induced cell death."

Link: https://www.mdpi.com/1422-0067/24/15/11969


r/StarvingCancer Mar 17 '24

If you would like to share your customized protocol...

4 Upvotes

Hi. If any of you would like to share your customized Starving Cancer protocol here that may be very helpful for others during their learning process.


r/StarvingCancer Mar 14 '24

Share your experience

3 Upvotes

This post is an invitation to share your experience if you would like to do so.