Study: glucose deprivation kills cancer cells due to ROS (not ATP)

[u/Unique-Public-8594]

Lead: Kang (National Cancer Center, Korea)

Published: International Journal Molecular Science, July 26, 2023

Type of study: cellular

Conclusion: "In this study, we found that glucose deprivation triggers cell death following an increase in ROS levels that was inversely correlated with ATP production. The increase of ROS induced cell death was concomitant with a decrease in ATP levels. Treatment with the reducing agent NAC reversed cancer cell death after restoration of ATP levels in cells under glucose deprivation. These findings suggest that ATP depletion resulting from glucose deprivation is not the cause of cancer cell death, but rather the result of cancer cell death caused by failure of ROS regulation. Indeed, glucose deprivation-induced cell death is independent from ATP depletion-induced cell death."

Link: https://www.mdpi.com/1422-0067/24/15/11969

[u/bsbailey66]

I’m hoping I’m doing the right thing: 5 day water fast, now low carb OMAD after an MRI showed a small tumor on the tail of my pancreas. 🙏🏻